Dr. Robert Chase
Robert Chase醫生總是親切友好，他樂於討好上司，尤其是在保護自身利益時。Chase幼時家庭富裕，但母親的酗酒而死，以及身為知名醫生的父親的失敗，在他心中形成陰影。當他知道罹患肺癌後，開始與父親疏遠。
Dr. Robert Chase is generally amiable and eager to please his boss, particularly if in doing so he’s also protecting his own interests. A former seminary student, Chase’s early life was one of privilege, but it was also marked by the death of his alcoholic mother and the failings of his renowned doctor father. Chase was estranged from his father when he learned of his death from lung cancer.
Dr. Eric Foreman
Eric Foreman醫生是House醫生管轄的診斷醫學部的組員。他是組員中最資深的，雖然他不願承認，但他對待病人時粗暴、不計一切的個性，與House十分相像。經歷一次瀕死經驗之後，Foreman曾短暫嘗試做個陽光、正面的人，但並不成功。
Dr. Eric Foreman is member of Dr. Gregory House’s diagnostic team at Princeton-Plainsboro Teaching Hospital. He’s the most senior of House’s fellows, and though he renounces his mentor’s abrasive, whatever-it-takes attitude toward patients, he’s more like House than he’d like to admit. Foreman briefly tried out a sunny and optimistic disposition following a near-death experience, but it didn’t take.
Dr. James Wilson
James Wilson醫生是普林斯頓綜合醫院腫瘤醫學部主任，也是House醫生最好的（甚至可說是唯一的）朋友。他與病人的相處之道完全與House相反：既富同情心、同理心，同時也充滿關懷。
Dr. James Wilson is the head of the oncology department at Princeton-Plainsboro Teaching Hospital. He’s Dr. Gregory House’s best, and arguably only, friend. His bedside manner could be described as the opposite of House’s: compassionate, interested, and empathetic.
Dr. Lisa Cuddy
Lisa Cuddy醫生是內科部主任，也是普林斯頓綜合醫院的院長，身攬重任的她，還得處理House醫生上任後引發的混亂。
Dr. Lisa Cuddy is the Dean of Medicine and Hospital Administrator at Princeton-Plainsboro Teaching Hospital, a job with myriad responsibilities, not the least of which is sorting through the chaos regularly left in the wake of her hospital’s world-renowned diagnostician, Dr. Gregory House.
Dr. Gregory House
Gregory House醫生是世界知名的診療師，任職於普林斯頓綜合醫院診斷醫學部門。他擅長解決醫學謎團，卻缺乏社交常識。他很少與病人談話、厭世，且不願意遵守任何他認為無理的規則。
Dr. Gregory House is the world-renowned chief of Princeton-Plainsboro Teaching Hospital’s diagnostic department. He is brilliant at solving medical mysteries but unconcerned with social niceties. Rarely speaking to patients, he’s misanthropic and apt to disregard any rules he deems unreasonable.