莫非定律就是—凡是可能出錯的就是會出錯。搬到克理夫蘭，她們因為可能被驅離而陷入窘境，不僅面臨財務損失、還頓失新戀情的好機會……，她們活潑的管理員（貝蒂懷特飾）還進了大牢！
在一切風波平息後的結果，Elka（貝蒂懷特飾）因偷竊被捕，三位主角們爲了保釋她而發起募款，生活仍然向她們拋出了變化球：Joy被迫與Roy訂婚以免被驅逐出境、Victoria在理財顧問吃牢飯時失去所有財產，於此同時Melanie和Pete向彼此示愛！誰說生活會在抵達克里夫蘭後便一帆風順呢？
本季客串嘉賓有珍妮佛樂芙休伊、梅蘭尼葛莉芬、瑪麗泰勒摩爾、韋恩奈特（曾於《歡樂單身派對》與《前夫總動員》演出）、卡爾雷納、朵莉絲羅伯茲（曾於《人人都愛雷蒙德》演出）、安東尼亞薩巴托、Jr.與修路易斯。
It’s Murphy’s Law – anything that can go wrong will go wrong. After moving to Cleveland, the ladies are in hot soup as they face potential deportation, sudden financial losses, chances at new love... and their feisty caretaker (played by Betty White) in jail.
In the aftermath of the tornado and Elka's (Betty White) arrest for stolen goods, the ladies hold a fundraiser to raise the money to pay Elka’s bail. Life continues to throw them curveballs, with Joy being forced to get engaged to Rick to avoid deportation and Victoria losing all her money when her financial advisor is imprisoned. Meanwhile, love is in the air as Melanie and Pete profess their love for each other. Whoever said that life will be all roses after moving to Cleveland?
Guest appearances this season include Jennifer Love Hewitt, Melanie Griffith, Mary Tyler Moore, Wayne Knight (Seinfeld and The Exes), Carl Reiner, John Mahoney, Doris Roberts (of Everybody Loves Raymond), Antonia Sabato, Jr., and Huey Lewis.
