尚恩瑞利和希瑟湯瑪斯曾在同一家醫院生孩子，並分享同一個病室，她們一見如故，立刻成為好友，哪怕出院後，她們也密不可分。雖然最初她們彼此扶持，但很快，她們的友誼便經歷了波折和考驗。兩年後，她們同時面對一個可怕的抉擇：拯救自己的家庭，還是犧牲自己的好友。其中一人註定要死於對方之手。
Shane Riley and Heather Thomas become fast friends in a shared hospital room after giving birth and are soon inseparable. Though they support each other at first, their friendship is headed for troubled waters, and two years later one will die by the other's hand in I Killed My Bff as Both women will have to make a terrible choice: save your family, or sacrifice your best friend.
